diff --git a/mindspore/ccsrc/backend/optimizer/graph_kernel/arithmetic_simplify.cc b/mindspore/ccsrc/backend/optimizer/graph_kernel/arithmetic_simplify.cc
index 908d33ca6d..a9fbd6035b 100644
--- a/mindspore/ccsrc/backend/optimizer/graph_kernel/arithmetic_simplify.cc
+++ b/mindspore/ccsrc/backend/optimizer/graph_kernel/arithmetic_simplify.cc
@@ -15,7 +15,10 @@
  */
 #include "backend/optimizer/graph_kernel/arithmetic_simplify.h"
 
+#include <algorithm>
 #include <list>
+#include <utility>
+#include <vector>
 #include "backend/optimizer/graph_kernel/graph_kernel_helper.h"
 #include "backend/kernel_compiler/common_utils.h"
 #include "backend/session/anf_runtime_algorithm.h"
diff --git a/mindspore/ccsrc/backend/optimizer/mem_reuse/mem_reuse.cc b/mindspore/ccsrc/backend/optimizer/mem_reuse/mem_reuse.cc
index ab7f69b102..b20a6f42fb 100644
--- a/mindspore/ccsrc/backend/optimizer/mem_reuse/mem_reuse.cc
+++ b/mindspore/ccsrc/backend/optimizer/mem_reuse/mem_reuse.cc
@@ -268,10 +268,10 @@ KernelRefCountPtr MemReuseUtil::GetKernelInputRef(const CNodePtr &kernel, size_t
   session::KernelWithIndex kernel_input;
   if (is_all_nop_node_) {
     // The graph does not remove the nop node.
-    kernel_input = AnfAlgo::VisitKernelWithReturnType(input_node, 0, false);
+    kernel_input = VisitKernelWithReturnType(input_node, 0, false);
   } else {
     // The graph removes the nop node.
-    kernel_input = AnfAlgo::VisitKernelWithReturnType(input_node, 0, true);
+    kernel_input = VisitKernelWithReturnType(input_node, 0, true);
   }
   if (IsPrimitive(kernel_input.first, prim::kPrimMakeTuple)) {
     MS_LOG(EXCEPTION) << "Input node [" << input_node->DebugString() << "]'s input " << input_idx << " is MakeTuple";
@@ -459,6 +459,10 @@ void MemReuseUtil::SetAllInfo(const KernelGraph *graph) {
 #ifdef MEM_REUSE_DEBUG
   MemReuseChecker::GetInstance().CheckMemReuseIR(total_refs_list_, kernel_def_ptr_list_, graph);
 #endif
+
+  auto context_ptr = MsContext::GetInstance();
+  MS_EXCEPTION_IF_NULL(context_ptr);
+  enable_visit_kernel_cache_ = context_ptr->get_param<bool>(MS_CTX_ENABLE_GRAPH_KERNEL);
 }
 
 uint8_t *MemReuseUtil::GetNodeOutputPtr(const AnfNodePtr &node, size_t index) const {
@@ -490,5 +494,22 @@ uint8_t *MemReuseUtil::GetNodeWorkSpacePtr(const AnfNodePtr &node, size_t index)
   }
   return ptr;
 }
+
+session::KernelWithIndex MemReuseUtil::VisitKernelWithReturnType(const AnfNodePtr &node, size_t i,
+                                                                 bool visit_nop_node) {
+  if (!enable_visit_kernel_cache_ || i != 0) {
+    return AnfAlgo::VisitKernelWithReturnType(node, i, visit_nop_node);
+  }
+
+  auto &cache =
+    visit_nop_node ? visit_kernel_with_return_type_in0pos_cache_ : visit_kernel_with_return_type_in0pos_skip_nop_cache_;
+  std::unordered_map<AnfNodePtr, session::KernelWithIndex>::iterator tag_iter;
+  if (auto iter = cache.find(node); iter == cache.end()) {
+    tag_iter = cache.insert({node, AnfAlgo::VisitKernelWithReturnType(node, i, visit_nop_node)}).first;
+  } else {
+    tag_iter = iter;
+  }
+  return tag_iter->second;
+}
 }  // namespace memreuse
 }  // namespace mindspore
diff --git a/mindspore/ccsrc/backend/optimizer/mem_reuse/mem_reuse.h b/mindspore/ccsrc/backend/optimizer/mem_reuse/mem_reuse.h
index 14c639fecc..a01814cc0c 100644
--- a/mindspore/ccsrc/backend/optimizer/mem_reuse/mem_reuse.h
+++ b/mindspore/ccsrc/backend/optimizer/mem_reuse/mem_reuse.h
@@ -18,11 +18,13 @@
 #define MINDSPORE_CCSRC_BACKEND_OPTIMIZER_MEM_REUSE_MEM_REUSE_H_
 #include <map>
 #include <memory>
+#include <unordered_map>
 #include <vector>
 #include "backend/optimizer/mem_reuse/kernel_refcount.h"
 #include "backend/session/anf_runtime_algorithm.h"
 #include "backend/session/kernel_graph.h"
 #include "backend/kernel_compiler/tbe/tbe_utils.h"
+#include "utils/ms_context.h"
 using mindspore::kernel::tbe::TbeUtils;
 namespace mindspore {
 namespace memreuse {
@@ -85,6 +87,7 @@ class MemReuseUtil {
   uint8_t *GetNodeOutputPtr(const AnfNodePtr &node, size_t index) const;
   uint8_t *GetNodeWorkSpacePtr(const AnfNodePtr &node, size_t index) const;
   bool is_all_nop_node() const { return is_all_nop_node_; }
+  session::KernelWithIndex VisitKernelWithReturnType(const AnfNodePtr &node, size_t i, bool visit_nop_node);
 
  private:
   int util_index_;
@@ -101,6 +104,11 @@ class MemReuseUtil {
   uint8_t *mem_base_{nullptr};
   // kernel_map_: key is the AnfNodePtr addr, value is the KernelDef
   std::map<KernelKey, KernelDefPtr> kernel_map_;
+
+  bool enable_visit_kernel_cache_{false};
+
+  std::unordered_map<AnfNodePtr, session::KernelWithIndex> visit_kernel_with_return_type_in0pos_cache_;
+  std::unordered_map<AnfNodePtr, session::KernelWithIndex> visit_kernel_with_return_type_in0pos_skip_nop_cache_;
 };
 using MemReuseUtilPtr = std::shared_ptr<MemReuseUtil>;
 }  // namespace memreuse
diff --git a/mindspore/ccsrc/runtime/device/gpu/gpu_kernel_runtime.cc b/mindspore/ccsrc/runtime/device/gpu/gpu_kernel_runtime.cc
index fb7fd4f602..71a5793c1b 100644
--- a/mindspore/ccsrc/runtime/device/gpu/gpu_kernel_runtime.cc
+++ b/mindspore/ccsrc/runtime/device/gpu/gpu_kernel_runtime.cc
@@ -51,6 +51,10 @@ static const size_t PARAMETER_OUTPUT_INDEX = 0;
 bool GPUKernelRuntime::SyncStream() { return GPUDeviceManager::GetInstance().SyncStream(stream_); }
 
 bool GPUKernelRuntime::Init() {
+  auto context_ptr = MsContext::GetInstance();
+  MS_EXCEPTION_IF_NULL(context_ptr);
+  enable_relation_cache_ = context_ptr->get_param<bool>(MS_CTX_ENABLE_GRAPH_KERNEL);
+
   if (device_init_ == true) {
     GPUMemoryAllocator::GetInstance().CheckMaxDeviceMemory();
     return true;
@@ -282,7 +286,7 @@ void GPUKernelRuntime::AllocInplaceNodeMemory(const session::KernelGraph *graph)
 
     auto primitive = AnfAlgo::GetCNodePrimitive(item[0]);
     auto output_index = GetValue<uint32_t>(primitive->GetAttr("inplace_output_index"));
-    auto device_address = AnfAlgo::GetMutableOutputAddr(item[0], output_index, false);
+    auto device_address = GetMutableOutputAddr(item[0], output_index, false);
     if (device_address->GetPtr() != nullptr) {
       continue;
     }
@@ -670,7 +674,7 @@ bool GPUKernelRuntime::AddMemorySwapTask(const AnfNodePtr &kernel, bool mock, bo
     MS_EXCEPTION_IF_NULL(need_swap_kernel);
     const HostAddress &host_address =
       mem_swap_manager_->QueryKernelHostAddr(need_swap_kernel, mem_swap_info.output_idx_);
-    auto device_address = AnfAlgo::GetMutableOutputAddr(need_swap_kernel, mem_swap_info.output_idx_, false);
+    auto device_address = GetMutableOutputAddr(need_swap_kernel, mem_swap_info.output_idx_, false);
 
     if (mem_swap_info.swap_kind_ == SwapKind::kDeviceToHost) {
       if (mem_swap_manager_->QueryKernelHostAddrIsDirty(need_swap_kernel, mem_swap_info.output_idx_)) {
@@ -821,10 +825,10 @@ bool GPUKernelRuntime::AllocKernelInputDynamicRes(const mindspore::AnfNodePtr &k
     DeviceAddressPtr device_address;
     if (mem_reuse_util_->is_all_nop_node()) {
       // Graph may be all nop nodes and not remove nop node, so this can not skip nop node.
-      device_address = AnfAlgo::GetPrevNodeMutableOutputAddr(kernel, i, false);
+      device_address = GetPrevNodeMutableOutputAddr(kernel, i, false);
     } else {
       // Graph may be "nop node + depend + node",  the input of node is the depend, so this case need skip nop node.
-      device_address = AnfAlgo::GetPrevNodeMutableOutputAddr(kernel, i, true);
+      device_address = GetPrevNodeMutableOutputAddr(kernel, i, true);
     }
 
     // Get in-place output_address
@@ -833,7 +837,7 @@ bool GPUKernelRuntime::AllocKernelInputDynamicRes(const mindspore::AnfNodePtr &k
       auto input_index = GetValue<uint32_t>(primitive->GetAttr("aggregate_input_index"));
       if (i == input_index) {
         auto skip_node = AnfAlgo::GetInputNode(utils::cast<CNodePtr>(kernel), input_index);
-        device_address = AnfAlgo::GetPrevNodeMutableOutputAddr(skip_node, 0, false);
+        device_address = GetPrevNodeMutableOutputAddr(skip_node, 0, false);
         MS_LOG(INFO) << "[inplace optimizer] aggregate: " << kernel->DebugString()
                      << ", skip: " << skip_node->DebugString() << ", address: " << device_address->GetMutablePtr();
       }
@@ -859,7 +863,7 @@ bool GPUKernelRuntime::AllocKernelOutputDynamicRes(const mindspore::kernel::Kern
   UpdateHostSwapOutQueue(mock);
   auto output_sizes = kernel_mod.GetOutputSizeList();
   for (size_t i = 0; i < output_sizes.size(); ++i) {
-    auto device_address = AnfAlgo::GetMutableOutputAddr(kernel, i, false);
+    auto device_address = GetMutableOutputAddr(kernel, i, false);
     MS_EXCEPTION_IF_NULL(device_address);
     if (device_address->ptr_ == nullptr && !AttemptMallocMem(device_address, output_sizes[i], mock)) {
       return false;
@@ -929,10 +933,10 @@ void GPUKernelRuntime::AllocCommunicationOpInputDynamicRes(const mindspore::AnfN
     DeviceAddressPtr device_address;
     if (mem_reuse_util_->is_all_nop_node()) {
       // Graph may be all nop nodes and not remove nop node, so this can not skip nop node.
-      device_address = AnfAlgo::GetPrevNodeMutableOutputAddr(kernel, i, false);
+      device_address = GetPrevNodeMutableOutputAddr(kernel, i, false);
     } else {
       // Graph may be "nop node + depend + node",  the input of node is the depend, so this case need skip nop node.
-      device_address = AnfAlgo::GetPrevNodeMutableOutputAddr(kernel, i, true);
+      device_address = GetPrevNodeMutableOutputAddr(kernel, i, true);
     }
     MS_EXCEPTION_IF_NULL(device_address);
     if (device_address->ptr_ == nullptr) {
@@ -958,7 +962,7 @@ void GPUKernelRuntime::AllocCommunicationOpOutputDynamicRes(const mindspore::Anf
   MS_EXCEPTION_IF_NULL(kernel_mod);
   auto output_sizes = kernel_mod->GetOutputSizeList();
   for (size_t i = 0; i < output_sizes.size(); ++i) {
-    auto device_address = AnfAlgo::GetMutableOutputAddr(kernel, i, false);
+    auto device_address = GetMutableOutputAddr(kernel, i, false);
     MS_EXCEPTION_IF_NULL(device_address);
     if (device_address->ptr_ == nullptr) {
       is_need_alloc_memory = true;
@@ -1013,7 +1017,7 @@ void GPUKernelRuntime::FreeKernelDynamicRes(const mindspore::AnfNodePtr &kernel)
       }
     }
 
-    auto kernel_with_index = AnfAlgo::GetPrevNodeOutput(kernel, i);
+    auto kernel_with_index = GetPrevNodeOutput(kernel, i);
     if (AnfAlgo::IsCommunicationOp(kernel_with_index.first)) {
       continue;
     }
@@ -1030,10 +1034,10 @@ void GPUKernelRuntime::FreeKernelDynamicRes(const mindspore::AnfNodePtr &kernel)
       DeviceAddressPtr device_address;
       if (mem_reuse_util_->is_all_nop_node()) {
         // Graph may be all nop nodes and not remove nop node, so this can not skip nop node.
-        device_address = AnfAlgo::GetPrevNodeMutableOutputAddr(kernel, i, false);
+        device_address = GetPrevNodeMutableOutputAddr(kernel, i, false);
       } else {
         // Graph may be "nop node + depend + node",  the input of node is the depend, so this case need skip nop node.
-        device_address = AnfAlgo::GetPrevNodeMutableOutputAddr(kernel, i, true);
+        device_address = GetPrevNodeMutableOutputAddr(kernel, i, true);
       }
       mem_manager_->FreeMemFromMemPool(device_address);
       device_address->set_status(DeviceAddressStatus::kInDevice);
@@ -1046,7 +1050,7 @@ void GPUKernelRuntime::FreeKernelDynamicRes(const mindspore::AnfNodePtr &kernel)
       continue;
     }
     if (kernel_ref_count_ptr->ref_count_dynamic_use_ == 0) {
-      auto device_address = AnfAlgo::GetMutableOutputAddr(kernel, i, false);
+      auto device_address = GetMutableOutputAddr(kernel, i, false);
       mem_manager_->FreeMemFromMemPool(device_address);
       device_address->set_status(DeviceAddressStatus::kInDevice);
     }
@@ -1062,6 +1066,71 @@ void GPUKernelRuntime::FreeKernelDynamicRes(const mindspore::AnfNodePtr &kernel)
     }
   }
 }
+
+DeviceAddressPtr GPUKernelRuntime::GetPrevNodeMutableOutputAddr(const AnfNodePtr &node, size_t i, bool visit_nop_node) {
+  if (!enable_relation_cache_) {
+    return AnfAlgo::GetPrevNodeMutableOutputAddr(node, i, visit_nop_node);
+  }
+
+  auto &addr_cache = visit_nop_node ? prev_node_mut_output_addr_cache_ : prev_node_mut_output_addr_skip_nop_node_cache_;
+  std::unordered_map<AnfNodePtr, std::vector<DeviceAddressPtr>>::iterator addr_iter;
+  if (auto iter = addr_cache.find(node); iter == addr_cache.end()) {
+    addr_iter = addr_cache.insert({node, {AnfAlgo::GetInputTensorNum(node), nullptr}}).first;
+  } else {
+    addr_iter = iter;
+  }
+
+  if (addr_iter->second[i] == nullptr) {
+    auto device_address = AnfAlgo::GetPrevNodeMutableOutputAddr(node, i, visit_nop_node);
+    addr_iter->second[i] = device_address;
+  }
+
+  return addr_iter->second[i];
+}
+
+DeviceAddressPtr GPUKernelRuntime::GetMutableOutputAddr(const AnfNodePtr &node, size_t i, bool visit_nop_node) {
+  if (!enable_relation_cache_) {
+    return AnfAlgo::GetMutableOutputAddr(node, i, visit_nop_node);
+  }
+
+  auto &addr_cache = visit_nop_node ? mut_output_addr_cache_ : mut_output_addr_skip_nop_node_cache_;
+  std::unordered_map<AnfNodePtr, std::vector<DeviceAddressPtr>>::iterator addr_iter;
+  if (auto iter = addr_cache.find(node); iter == addr_cache.end()) {
+    auto kernel_mod = AnfAlgo::GetKernelMod(node);
+    MS_EXCEPTION_IF_NULL(kernel_mod);
+    auto output_sizes = kernel_mod->GetOutputSizeList();
+    addr_iter = addr_cache.insert({node, {output_sizes.size(), nullptr}}).first;
+  } else {
+    addr_iter = iter;
+  }
+
+  if (addr_iter->second[i] == nullptr) {
+    auto device_address = AnfAlgo::GetMutableOutputAddr(node, i, visit_nop_node);
+    addr_iter->second[i] = device_address;
+  }
+
+  return addr_iter->second[i];
+}
+
+session::KernelWithIndex GPUKernelRuntime::GetPrevNodeOutput(const AnfNodePtr &node, size_t i) {
+  if (!enable_relation_cache_) {
+    return AnfAlgo::GetPrevNodeOutput(node, i);
+  }
+
+  std::unordered_map<AnfNodePtr, std::vector<session::KernelWithIndex>>::iterator addr_iter;
+  if (auto iter = prev_node_output_cache_.find(node); iter == prev_node_output_cache_.end()) {
+    addr_iter = prev_node_output_cache_.insert({node, {AnfAlgo::GetInputTensorNum(node), {nullptr, 0}}}).first;
+  } else {
+    addr_iter = iter;
+  }
+
+  if (addr_iter->second[i].first == nullptr) {
+    auto kernel_with_index = AnfAlgo::GetPrevNodeOutput(node, i);
+    addr_iter->second[i] = kernel_with_index;
+  }
+
+  return addr_iter->second[i];
+}
 }  // namespace gpu
 }  // namespace device
 }  // namespace mindspore
diff --git a/mindspore/ccsrc/runtime/device/gpu/gpu_kernel_runtime.h b/mindspore/ccsrc/runtime/device/gpu/gpu_kernel_runtime.h
index 346eb7c6a9..929a69dc86 100644
--- a/mindspore/ccsrc/runtime/device/gpu/gpu_kernel_runtime.h
+++ b/mindspore/ccsrc/runtime/device/gpu/gpu_kernel_runtime.h
@@ -18,12 +18,14 @@
 #define MINDSPORE_CCSRC_RUNTIME_DEVICE_GPU_GPU_KERNEL_RUNTIME_H_
 
 #include <string>
+#include <map>
 #include <memory>
 #include <vector>
 #include <set>
 #include <utility>
 #include <unordered_map>
 #include <unordered_set>
+#include "backend/session/anf_runtime_algorithm.h"
 #include "runtime/device/kernel_runtime.h"
 #include "runtime/device/kernel_runtime_manager.h"
 #include "backend/optimizer/mem_reuse/mem_swap_manager.h"
@@ -96,6 +98,11 @@ class GPUKernelRuntime : public KernelRuntime {
   void UpdateHostSwapOutQueue(bool mock);
   void ClearSwapInfo(bool mock);
   void AllocInplaceNodeMemory(const session::KernelGraph *graph);
+
+  DeviceAddressPtr GetPrevNodeMutableOutputAddr(const AnfNodePtr &node, size_t i, bool visit_nop_node);
+  DeviceAddressPtr GetMutableOutputAddr(const AnfNodePtr &node, size_t i, bool visit_nop_node);
+  session::KernelWithIndex GetPrevNodeOutput(const AnfNodePtr &node, size_t i);
+
   std::unordered_map<uint32_t, MemReuseUtilPtr> mem_reuse_util_map_;
   std::unordered_map<uint32_t, MemSwapManagerPtr> mem_swap_map_;
   std::unordered_map<uint32_t, bool> is_first_step_map_;
@@ -105,6 +112,14 @@ class GPUKernelRuntime : public KernelRuntime {
 
   MemReuseUtilPtr mem_reuse_util_{nullptr};
   MemSwapManagerPtr mem_swap_manager_{nullptr};
+
+  bool enable_relation_cache_{false};
+
+  std::unordered_map<AnfNodePtr, std::vector<DeviceAddressPtr>> prev_node_mut_output_addr_cache_;
+  std::unordered_map<AnfNodePtr, std::vector<DeviceAddressPtr>> prev_node_mut_output_addr_skip_nop_node_cache_;
+  std::unordered_map<AnfNodePtr, std::vector<DeviceAddressPtr>> mut_output_addr_cache_;
+  std::unordered_map<AnfNodePtr, std::vector<DeviceAddressPtr>> mut_output_addr_skip_nop_node_cache_;
+  std::unordered_map<AnfNodePtr, std::vector<session::KernelWithIndex>> prev_node_output_cache_;
 };
 MS_REG_KERNEL_RUNTIME(kGPUDevice, GPUKernelRuntime);
 }  // namespace gpu